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Highlights of special issue “Genome Editing in Agriculture: Technology, Applications and Regulations”

Yaofeng ZHAO, Caixia GAO, Sen WU

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 121-122 doi: 10.15302/J-FASE-2019317

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The development and application of genome editing technology in ruminants: a review

Mengke YUAN, Yuanpeng GAO, Jing HAN, Teng WU, Jingcheng ZHANG, Yongke WEI, Yong ZHANG

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 171-180 doi: 10.15302/J-FASE-2019302

Abstract: However, new breeding methods combined with genome editing and somatic cell nuclear transfer or microinjectionRecent advances in precise genome editing technologies, especially clustered regularly interspaced shortediting technology in ruminants.It is concluded that the production of gene-edited ruminants is feasible and through improvements in genomeediting technology it is possible to help feed the world.

Keywords： bioreactors     breeding     engineered endonucleases     genome editing     ruminants    

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GENOME EDITING: A GROUND BREAKING RESEARCH HAS BEEN RANKED TOP 10 ENGINEERING FRONTS FROM 2017 TO 2021

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 2,   Pages 309-311 doi: 10.15302/J-FASE-2022440

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A brief review of genome editing technology for generating animal models

Haoyi WANG, Sen WU, Mario R. CAPECCHI, Rudolf JAENISCH

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 123-128 doi: 10.15302/J-FASE-2019309

Abstract:

The recent development of genome editing technologies has given researchers unprecedented power toThis mini-review briefly summarizes the development of major genome editing tools, focusing on the application

Keywords： animal model     CRISPR     genome editing     TALEN     ZFN    

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Embryo-mediated genome editing for accelerated genetic improvement of livestock

Zachariah MCLEAN, Björn OBACK, Götz LAIBLE

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 148-160 doi: 10.15302/J-FASE-2019305

Abstract: Genome editing technology with its ability to directly introduce beneficial sequence variants offersHowever, embryo-mediated precision editing by homology-directed repair (HDR) mechanisms is currentlyThis review provides a summary of genome editing in bovine embryos and proposes an embryo-mediated acceleratedbreeding scheme that overcomes the present efficiency limitations of HDR editing in bovine embryos.It integrates embryo-based genomic selection with precise multi-editing and uses embryonic cloning with

Keywords： animal breeding     cattle     cloning     CRISPR/Cas9     cytoplasmic injection     embryo     genome editing     germline chimaeras    

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Genome-edited crops: how to move them from laboratory to market

Kunling CHEN, Caixia GAO

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 181-187 doi: 10.15302/J-FASE-2020332

Abstract:

Recent breakthroughs in CRISPR technology allow specific genome manipulation of almost all crops andRationally-based regulation and widespread public acceptance are needed to propel genome-edited crops

Keywords： CRISPR/Cas     genome editing     base editing     precision breeding     regulation    

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Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas

Lan Yu, Xun Tian, Chun Gao, Ping Wu, Liming Wang, Bei Feng, Xiaomin Li, Hui Wang, Ding Ma, Zheng Hu

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 497-508 doi: 10.1007/s11684-017-0572-1

Abstract: Meanwhile, rapidly evolving genome-editing techniques targeting viral DNA/RNA have emerged as novel therapeuticThis review discusses the recent advances of genome-editing tools for treating tumorigenic viruses andtheir corresponding cancers, the challenges that must be overcome before clinically applying such genome-editing

Keywords： genome-editing tools     tumorigenic virus     delivery method     off-target effect     virus-related carcinoma    

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PAM-Expanded Streptococcus thermophilus Cas9 C-to-T and C-to-G Base Editors for Programmable Base Editing Article

Hongyuan Zhang, Yifei Zhang, Wei-Xiao Wang, Weizhong Chen, Xia Zhang, Xingxu Huang, Wei Chen, Quanjiang Ji

Engineering 2022, Volume 15, Issue 8,   Pages 67-77 doi: 10.1016/j.eng.2022.02.013

Abstract: new base editors (CTBE and CGBE) capable of C-to-T or C-to-G conversions with dramatically enhanced editingproduct purity and multiplexed editing capacity in Mycobacterium smegmatis (M. smegmatisfirst developed and characterized CTBE and CGBE in M. smegmatis, and then applied CTBE for genomeediting in M. tuberculosis.

Keywords： CRISPR     Cas9     Mycobacterium tuberculosis     Genome editing     Base editing    

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Base editing in pigs for precision breeding

Ruigao SONG, Yu WANG, Yanfang WANG, Jianguo ZHAO

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 161-170 doi: 10.15302/J-FASE-2019308

Abstract: Base editing has recently been developed as the latest gene-editing tool that can directly make changesThis review summarizes gene-editing developments and highlights recent genetic dissection related toSNPs in major economic traits which may have the potential to be modified using SNP-editing applicationsIn addition, limitations and future directions of base editing in pig breeding are discussed.

Keywords： base editing     genetic improvement     pigs     single nucleotide polymorphisms    

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Base editing technology

Yidi SUN, Erwei ZUO, Hui YANG

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 227-228 doi: 10.15302/J-FASE-2020321

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Search-and-replace editing of genetic information

Yao LIU, Xingxu HUANG, Xiaolong WANG

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 231-232 doi: 10.15302/J-FASE-2020322

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Exploring the cancer genome in the era of next-generation sequencing

Hui Dong, Shengyue Wang

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 48-55 doi: 10.1007/s11684-012-0182-x

Abstract:

The emergence of next-generation sequencing technologies has led to dramatic advances in cancer genomeComprehensive analysis of cancer genomes through approaches of whole genome, exome, and transcriptomeThe present study briefly reviews the recent pioneering studies on cancer genome sequencing and provides

Keywords： next-generation sequencing     cancer genome     whole genome sequencing     exome     transcriptome    

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Liquid metal material genome: Initiation of a new research track towards discovery of advanced energy

Lei WANG, Jing LIU

Frontiers in Energy 2013, Volume 7, Issue 3,   Pages 317-332 doi: 10.1007/s11708-013-0271-9

Abstract: Inspired by the Material Genome Initiative as issued in 2011 by the United States of America, a morespecific and focused project initiative was proposed in this paper—the liquid metal material genome aimedtheoretical strategies and experimental methods in the research and development of liquid metal material genomeThe liquid metal material genome proposal as initiated in this paper will accelerate the process of finding

Keywords： liquid metal material genome     energy material     material discovery     advanced material     room-temperature liquid    

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Gene-editing in plants no longer requires tissue culture

Yi ZHANG, Michael PALMGREN

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 229-230 doi: 10.15302/J-FASE-2020330

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Transforming bacterial disease surveillance and investigation using whole-genome sequence to probe the

Biao Kan, Haijian Zhou, Pengcheng Du, Wen Zhang, Xin Lu, Tian Qin, Jianguo Xu

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 23-33 doi: 10.1007/s11684-017-0607-7

Abstract:

Two decades have passed since the first bacterial whole-genome sequencing, which provides new opportunityfor microbial genome.In recent years, genome sequencing techniques and bioinformatics have developed rapidly, which has resultedBacterial whole-genome sequencing and bioinformatic computing allow genotyping to satisfy the requirementsIn this review, we outline the significance and summarize the roles of bacterial genome sequencing in

Keywords： genome sequencing     genomic epidemiology     bacteria     surveillance     infectious diseases    

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Title Author Date Type Operation

Highlights of special issue “Genome Editing in Agriculture: Technology, Applications and Regulations”

Yaofeng ZHAO, Caixia GAO, Sen WU

Journal Article

The development and application of genome editing technology in ruminants: a review

Mengke YUAN, Yuanpeng GAO, Jing HAN, Teng WU, Jingcheng ZHANG, Yongke WEI, Yong ZHANG

Journal Article

GENOME EDITING: A GROUND BREAKING RESEARCH HAS BEEN RANKED TOP 10 ENGINEERING FRONTS FROM 2017 TO 2021

Journal Article

A brief review of genome editing technology for generating animal models

Haoyi WANG, Sen WU, Mario R. CAPECCHI, Rudolf JAENISCH

Journal Article

Embryo-mediated genome editing for accelerated genetic improvement of livestock

Zachariah MCLEAN, Björn OBACK, Götz LAIBLE

Journal Article

Genome-edited crops: how to move them from laboratory to market

Kunling CHEN, Caixia GAO

Journal Article

Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas

Lan Yu, Xun Tian, Chun Gao, Ping Wu, Liming Wang, Bei Feng, Xiaomin Li, Hui Wang, Ding Ma, Zheng Hu

Journal Article

PAM-Expanded Streptococcus thermophilus Cas9 C-to-T and C-to-G Base Editors for Programmable Base Editing

Hongyuan Zhang, Yifei Zhang, Wei-Xiao Wang, Weizhong Chen, Xia Zhang, Xingxu Huang, Wei Chen, Quanjiang Ji

Journal Article

Base editing in pigs for precision breeding

Ruigao SONG, Yu WANG, Yanfang WANG, Jianguo ZHAO

Journal Article

Base editing technology

Yidi SUN, Erwei ZUO, Hui YANG

Journal Article

Search-and-replace editing of genetic information

Yao LIU, Xingxu HUANG, Xiaolong WANG

Journal Article

Exploring the cancer genome in the era of next-generation sequencing

Hui Dong, Shengyue Wang

Journal Article

Liquid metal material genome: Initiation of a new research track towards discovery of advanced energy

Lei WANG, Jing LIU

Journal Article

Gene-editing in plants no longer requires tissue culture

Yi ZHANG, Michael PALMGREN

Journal Article

Transforming bacterial disease surveillance and investigation using whole-genome sequence to probe the

Biao Kan, Haijian Zhou, Pengcheng Du, Wen Zhang, Xin Lu, Tian Qin, Jianguo Xu

Journal Article